Injuries to Robbie Henshaw and Garry Ringrose, who picked up a knock in training, have led to a start for Chris Farrell at outside centre, with Rob Kearney returning at full-back after a thigh injury.
Devin Toner has been ruled out of the remainder of Ireland'sSix Nations championship with an ankle injury.
"We could be struck with a similar circumstance to what we had four years ago", Irelandcoach Joe Schmidt said of the changes, referencing the 2015 World Cup when his side did not have the depth to cope with a string of frontline absentees.
"It's just a bit of aggravation after having a knock", Schmidt said of Henshaw. It's a knock on top of a knock.
Beirne is targeting a return from his knee injury in time for Ireland's round three match against Italy on 24 February, while Henderson is hoping to recover from a finger injury in time to feature in the final two rounds against France and Wales. But if you get another bump on it, it debilitates you quickly and then you have to make another change.
"So he'll be a loss, as any great player is, but when these things happen it gives an opportunity for somebody else and I thought Quinn Roux was great when he came on".
"We're just going to have to forge ahead, but it's an exciting opportunity to give Chris Farrell a run against Scotland. He's coming back to form after a long lay-off", Schmidt added.
James Ryan and Quinn Roux were playing Scotland this weekend, with Ultan Dillane the backup for his first test since November 2017.
Captain Rory Best joins Cian Healy and Tadhg Furlong in the front-row with James Ryan partnering Roux in the second-row.
Cases of equine influenza had been reported in recent weeks, originally in France but spreading to Ireland and Britain. BHA procedures state that a racecourse can not race for at least four days following a deep clean having taken place.
Bahraini Hakeem al-Araibi, center, leaves the criminal court in Bangkok , Thailand , Bangkok , Thailand, Monday, Feb. 4, 2019. Al-Araibi, 25, a former Bahraini national team player, has said he fled his home country due to political repression.
And, it's clear he wants to do it because in order to void the contract Foles must pay the Eagles $2 million. The Eagles have informed Foles they are picking up that option, according to ESPN's Tim McManus .
The company on Twitter apologized to its customers and asked for patience while it once again sorted out the issue. Wells Fargo was hit by a major outage Thursday morning, leaving customers' funds frozen for hours.
Turkish officials have been frustrated by what they say is a lack of co-operation by Riyadh and have called for an global inquiry. Khashoggi was lured into the Saudi consulate in Istanbul on the promise of being given documents that would help him remarry.
A statement from a family spokesman said: 'He passed away peacefully after a short illness with those closest to him by his side. Veteran British actor Albert Finney holds up his BAFTA award at the British Academy Film Awards in London February 25, 2001.
Raptors strike before trade deadline, acquire Marc Gasol
Wright is a nice wing to add, and extra picks are never bad, but a second-rounder from the Raptors isn't exactly that exciting. He spent 11 seasons with the Grizzlies and is the franchise's all-time leader in points, rebounds, blocks and made field goals.
President Trump has medical checkup
Trump had his second annual physical at Walter Reed National Military Medical Center Friday, after the now-infamous Dr. White House Deputy Press Secretary Hogan Gidley on Thursday told CNN that Trump was working on improving his diet.
Princess Steps Into Thailand's Tense Political Fray
She received her Bachelor of Science from MIT and went on to receive her Masters in public health at the University of California. Thailand has not had a royal as premier since becoming a constitutional monarchy in 1932.
Gay, Langley Share AT&T Pebble Beach Lead
Thursday morning was supposed to bring an early wake-up call for John Rollins here at the AT&T Pebble Beach National Pro-Am. Jason Day also fired a 65 at Monterey but world number 155 Brian Gay and 285th-ranked Scott Langley shot 64s.